Temperature-sensitive mutants of human cytomegalovirus
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چکیده
منابع مشابه
Temperature-sensitive mutants of bacteriophage mu.
Temperature-sensitive mutants of bacteriophage Mu, which grow at 32 C but not at 42 C, have been isolated. These mutants fall into two groups. Group 1 mutants fail to lyse host cells at nonpermissive temperatures, whereas lysis occurs normally with the group 2 mutants. All of the group 1 mutants apparently belong to the cistrons mapping to the left of gene C, whereas the group 2 mutants have le...
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Mutants of a marine luminous bacterium, in which the ability to emit light is conditional upon temperature, have been isolated. The mutants obtained fall into three classes, which are readily distinguishable by both in vivo and in vitro criteria. In one class an altered, more temperature-sensitive luciferase is produced; in a second, the luciferase is actually not produced at the higher tempera...
متن کاملTemperature-Sensitive Mutants of Measles Virus
were isolated after mutagenesis by 5-azacytidine, 5-fluorouracil, or proflavine. The restricted replication of all mutants at 39 C was blocked subsequent to cell penetration and could not be attributed to heat inactivation of virus infectivity. Complementation analysis was made possible through the use of poly-L-ornithine. The members of one complementation group exhibited wild-type RNA synthes...
متن کاملTemperature-Sensitive Mutants of Vesicular Stomatitis Virus
Different temperature-sensitive mutants of vesicular stomatitis virus have been characterized in terms of their ability to induce synthesis of viral ribonucleic acid (RNA) in BHK-21 cells at 39 C (the restrictive temperature for these mutants). Mutants belonging to complementation groups I and IV (and probably II) did not induce actinomycin-resistant RNA synthesis in infected cells incubated at...
متن کاملTemperature-sensitive mutants of Neisseria gonorrhoeae.
Nine temperature-sensitive (Ts) mutants of Neisseria gonorrhoeae strain 49191 were isolated. They were proven to be different from each other by results of transformation experiments. None of the Ts mutations appeared to be linked to antibiotic resistance genes from strain 24392. However, Ts-9 demonstrated 8% linkage with a nalidixic acid resistance marker from strain RW-2.
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1977
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.24.1.416-418.1977